NASA is discussing "what they want to know next 30 years [science]” and “what it takes to make that happens [technology]” in order to answer the fundamental questions “Are we alone?” and “What is the origin and history of our solar system and extrasolar systems?” under the frame of (i) Discovery and (ii) Exploration of other worlds and cosmos and (iii) Development of necessary technologies. Searching for life and habitable environments outside Earth will be a driving force for many NASA projects. Next 30 years will be the decades of “sample returns” from asteroids and Mars. With the accumulation of scientific knowledge and technology through various missions including the exploration to Mars, NASA is paving a way for human exploration and noticeably shifting its focus to the water world Europa. When James Webb Telescope is put into the orbit in year 2018, it will detect and analyze water, oxygen, methane, ozone, temperature, surface pressure and many more on planets, especially seven exoplanets of TRAPPIST 1 solar system. The close comparative study of exoplanets and water and icy worlds in our solar system is expected as an effort to understand “life and its origin”. NASA will continue to examine the possibility to transform Mars into a habitable environment. This talk is intended to show the big picture under the overarching themes of NASA missions so that audience have a good foundation from which they can nurture their abilities to forecast what NASA and thus the international space exploration community try to achieve and where they will be next 10 years, 20 years, and 30 years.