<p><span style="font-size: 12pt; background-color: white;"><font color="black" face="Segoe UI"><span lang="en-US">Chile is widely recognized as the leading site for ground-based observational astronomy in the world, with many first-class facilities and a growing local research community. In an effort to promote bilateral collaborations in astronomy, the Chinese Academy of Sciences (CAS) has recently established an office in Chile to coordinate its programs. I will introduce the operations of this office and its recent activities, then discuss its long-term mission and the prospect of international cooperation in the Southern Hemisphere.</span></font></span></p>